专业型硕导
张晓丹
日期:2022-05-17 信息来源: 点击数:


张晓丹, 女, 副教授

韩国中央大学药学院生药学博士,浙江省药学会委员,韩国药学会会员,曾任韩国首尔麻浦区药师会中文讲师

研究方向:天然产物活性物质基础及生药开发与评价研究


学习工作经历:

(1) 2002年9月-2006年7月,中南大学,制药工程专业,本科

(2) 2006年9月-200812月,中南大学,制药工程专业,研究生(保送)研究方向为天然药物化学,导师:刘向前教授;

(3) 20093月-2013年2月韩国中央大学药学院生药学,博士,导师Professor Whang Wankyunn;

4)2013年7月至今,0029cc金沙贵宾会生命科学学院,讲师。


科研项目成果经历

(1)工作阶段:

“新浙八味之三叶青”质量标志物及道地性特征挖掘关键技术研究,浙江省基础公益项目,2022-2025年,主持,到账经费:10万元;

次生代谢物质量控制与检测技术标准研究,国家级重点子课题(215万元),2016-2019年,校内主持,到账经费:28万元;

基于Aβ25-35诱导PC12细胞氧化损伤保护作用的2种五加叶药效物质基础、构效关系及机制研究,浙江省自然科学基金,省部级一般,5万元,2014年,1/6,已结题;

0029cc金沙贵宾会科研启动基金,基于Aβ25-35诱导PC12 细胞氧化损伤保护作用的糙叶五加叶多酚类成分富集、构关系及机制研究、2014/01-2016/123万元、在研、主持。

新型透皮吸收抗氧化药物的制备技术开发,横向,2015年,主持;

肿瘤靶标蛋白TNIK磷酸化促乳腺癌生长转移机制及其靶向抑制剂研究,国家级一般, 2016年,5/9;

负调控因子SmMYB39与正调控因子SmbHLH7协同调控丹参酚酸类成分生物合成的分子机制,国家级一般, 2016年,7/10;

铁皮石斛、三七、半夏转录组测序及开发应用,横向,130万元,3/8;

乳核散结胶囊标准提高及标准化建设项目,横向,20万元,3/5;

水果生产基地关键技术与示范推广技术服务,横向,48万元,4/5;

珍稀中药材高效组培繁育技术及相关产品开发,横向,20万元,10/10。

(2)博士阶段:

2010.3 ~ 2010.10 以主要参与人参与韩国国家食品药品安全厅“对照生药材基源鉴定,制造及资源再评价(柴胡,桃仁,陈皮,姜黄,莪术,郁金等)”子课题。
2010.10 ~ 2011.3 以主要参与人参加韩国保健福祉部“韩药材评价技术科学化研究”子课题(茴香),“韩国药材生理活性分析及含量监测研究”子课题 (益母草);
2011.3 ~ 2011.12 以主要参与人参加韩国保健福祉部“韩药材评价技术科学化研究”子课题(远志),并创新开发了“远志”的质量控制方法,优于 2010 版中国药典。“韩国药材生理活性分析及含量监测研究”子课题 (木香);
2009.3 ~ 2009.11 以主要参与人参加韩国国家食品药品安全厅“韩国对照生药材基源鉴定,制造及资源再评价(当归,羌活,藁本,前胡,川芎等)” 参加韩国保健福祉部“韩药材评价技术科学化研究”子课题(香附子),“韩国药材生理活性分析及含量监测研究”子课题(栀子);
2011.9 ~ 2012.3 以主要参与人参加韩国东亚制药公司“基于朝鲜淫羊藿抗阿尔茨海莫病的新药开发与研究”项目,开发了朝鲜淫羊藿中抗乙酰胆碱酯酶活性成分分离鉴定及定量研究。


SCI期刊论文发表情况:

[1] Xianxian Nie, Ziying Wang, Jingxin Ren, Xiangqian Liu, Zhong Xu, Wankyunn Whang, Zongsuo Liang*, Xiaodan Zhang*. Chemical composition and antioxidant activity of Purple Eleutherococcus leaves' essential oil grown in Yunnan province of China.Food Science and Technology. 2022,(42),e76821.[DOI 10.1590/fst.76821]

[2] Yue CHEN, Majie GONG, Xianxian NIE, Zhechen QI, Xiangqian LIU, Qinghao JIN, Dongfeng YANG, Xiaodan ZHANG*, Characterization of botanical origin of selected popular purple Eleutherococcus tea grown in Yunnan province of China and quantification of Its anthocyanins using spectrophotometric method.Food Science and Technology. 2022,42,e91121. [DOI 10.1590/fst.91121]

[3] 俞佳妮,贾巧君,叶子弘,杨东风,侯卓妮,肖艺,张晓丹*.二氢丹参酮Ⅰ标准样品的研制.中国计量大学学报. 2021,2(32), 170-175.

[4] 娄港归,夏杰,杨健,王宏鹏,梁宗锁,肖艺,李振达,张煜,刘志超,施宛丽,张晓丹*,杨东风. 基于UPLC-Q-TOF-MS/MS代谢组学的铁皮石斛和玫瑰石斛化学成分差异研究.药学学报,2021, 56(12):14.

[5] 夏杰,贾巧君,叶子弘,杨东风,侯卓妮,肖艺,张晓丹*.丹参新酮标准样品的研制.湖南中医药大学学报. 20214111):1711-1716.

[6] Xiaodan Zhang, Yesheng Cen, Zhechen Qi, Dongfeng Yang, Ziying Wang, Zhuoni Hou, Zongsuo Liang. Simultaneous determination of 17 constituents of Chinese wild Radix Salvia miltiorrhiza from different geographical areas by ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry, Current Phaemaceutical analysis, 2020, 3(16), 280-290.

[7] Xiaodan Zhang#, Yange Yu#, Dongfeng Yang, Zhechen Qi, Ruizhen Liu, Fengtao Deng, Zengxuan Cai, Ying Li, Yanfang Sun*, and Zongsuo Liang*, Chemotaxonomic variation in secondary metabolites contents and their correlation between environmental factors in Salvia miltiorrhiza Bunge from natural habitat of China, IND CROP PROD, 2018, 113, 335-347.

[8] Xiaodan Zhang#, Yange Yu#, Yesheng Cen, Dongfeng Yang, Zhechen Qi, Zhuoni Hou, Shuanglai Han, Zengxuan Cai, and Kuancheng Liu*, Bivariate Correlation Analysis of the Chemometric Profiles of Chinese Wild Salvia miltiorrhiza Based on UPLC-Qqq-MS and Antioxidant Activities, Molecules, 2018,23,538. [Doi:10.3390/molecules23030538]

[9] Gbago Onivogui, Xiaodan Zhang, Mohamed Diaby, Clotaire Gna Maomy, and Yuanda Song*, Potential nutritional and antioxidant activity of various solvent extracts from leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used in folk medicine, Brazilian Journal of Pharmaceutical Sciences, 2017, 53. [DOI: 10.1590/s2175-97902017000216040]

[10] Xiaodan Zhang#, Zhi Li#, Guozhu Liu, Xiang Wang, Okkyoung Kwon, Hyeongkyu Lee, Wankyunn Whang, and Xiangqian Liu*, Quantitative determination of 15 bioactive triterpenoid saponins in different parts of Acanthopanax henryi by HPLC with charged aerosol detection and confirmation by LC-ESI-TOF-MS, Journal of seperation science, 2016, 39 (12), 2252-2262.

[11] Xiaodan Zhang, Xinqi Zhou, Xiangqian Liu, Xiaolong Li, and Wankyunn Whang, Development and Application of an HPLC-UV Procedure to Determine Multiple Flavonoids and Phenolics in Acanthopanax Leaf Extracts, J CHROMATOGR SCI, 2015, 54 (4), 574-582.

[12] Bingnan Han, Tingting Liang, Lawrence Jordan Keen, Tingting Fan, Xiaodan Zhang, Lin Xu, Qi Zhao, Shuping Wang, and Houwen Lin*, Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity, ORG LETT, 2018, 20,578-581.

[13] Xiaojun Li, Ling Dai, Zhi Li., Xiaodan Zhang, Xiangqian Liu *, Qingpeng. Zou, and Xia Xie. Anti-inflammatory Activities of Lupane-triterpenoids In Vitro and Their Phytochemical Fingerprinting from Leaves of Acanthopanax gracilistylus, Natural Product Sciences,2015, 21(2) : 104-110.

[14] Xiaojun Li, Weichao Huang, Zhi Li, Xiaodan Zhang, Xiangqian Liu * , Okkyoung Kwon, and Hyeongkyu Lee. Chemical Composition, Anti-inflammatory and Cytotoxic Activities of Essential Oils from Different Parts of Acanthopanax evodiaefolius. Nat Prod Res Dev 2015,27: 1156-1161.

[15] Xiaodan Zhang, Xiangqian Liu, Y.H. Kimand Wankyunn Whang* Chemical constituents in leaves of Acanthopanax henryi and antioxidant and acetyl cholinesterase inhibitory activities of some their major metabolites: A Potential Complementary Source against Alzheimer’s Disease. Archives of Pharmacal Research 2014,37(15):606-616.

[16] Xiaodan Zhang# Mihyue OhSeulgi Kim, Jimin Kim Hyeyeon Kim Sungun Kim Peter J. Houghtonand Wankyunn Whang *. Epimediphine, a novel alkaloid from Epimedium koreanum inhibits acetylcholinesterase. Natural Product Research 2013, 27(12): 1067-1074.


发明专利情况:

实审阶段专利5项:

一种白簕叶片中总多酚分离纯化工艺(201710564656X)

一种白簕叶总多酚的超声细胞破碎提取工艺(201710564668.2);

一种用于白簕中总多酚纯化的大孔树脂的制备方法(201710564644.7);

白簕叶总多酚的用途(201811166127.5);

树舌灵芝乙醇提取物及其用途(201811166127.5)





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