专业型硕导
丁先锋
日期:2022-05-17 信息来源: 点击数:

丁先锋,教授,硕士研究生导师。浙江省优秀教师,先后任职于江南大学和0029cc金沙贵宾会,中国转化医学联盟理事,浙江省细胞生物学常务理事,浙江省转化医学学会理事,浙江省原子能农学会理事,杭州市小营巷新联会理事。

长期从事肿瘤DNA及RNA研究的技术开发工作,开展肿瘤相关保守非编码RNA的筛选与功能鉴定。建立了微量血清特异的miRNA分离纯化技术;利用高通量荧光定量PCR,系统发现并验证肿瘤相关的血清microRNA;同时对miRNA在肿瘤发生中的生物学功能展开了一些研究,希望在肿瘤早期标志物的发现和应用、以及肿瘤血清miRNA的生物学功能等方面获得一些成果,对肿瘤的早期诊断提供一种新型的临床诊断技术,这些研究成果获2016年浙江省自然科学三等奖,2020年浙江省自然科学进步三等奖。2008在美国休斯顿大学和LC Science公司开展基因芯片相关课题研究工作,2015年在美国密西西比大学开展LncRNA与肿瘤的研究,LncRNA AK023948在AKT中的正向调控研究2017年发表在Naturecommunication,该论文ESI高被引收录。主持和参加国家863项目,浙江省自然科学基金,浙江省科技厅重大项目等纵向项目10余项,主持横向项10多项,发表论文80余篇,SCI50余篇,近5年google学术引用超过2150单篇论文他引(google)369多次,申请专利近20项,授权专利10余项。

                     主要研究方向:肿瘤非编码RNA的表达和机理研究

                     联系方式:bdd114@163.com,xfding@zstu.edu.cn


代表性论文

1)Y Wang,X Miao, Y Jiang, Z Wu, X Zhu,H Liu, X Wu,J Cai,X Ding*,W Gong,,Cell Death and Disease(2022) 13:146 -155

2)Gabriel B. K. Sasa, C Xuan, M Chen, Z Jiang,X Ding*, Clinicopathological implications of lncRNAs, immunotherapy and DNA methylation in lung squamous cell carcinoma: a narrativereview.Transl Cancer Res2021;10(12):5406-5429

3)J Xu, K Wu, QJia,X. Ding*, Roles of miRNA and lncRNA in triple-negative breast cancer.Journal of Zhejiang University-Science B(Biomedicine& Biotechnology), 2020.21(9):673-689.

4)L Zheng, Y Zhang, Y Fu, H Gong, J Guo, K Wu, Q Jia andX Ding*,,Bioscience Reports,2019: 39 BSR20181284

5)Q Yang, Q Wan, L Zhang, Y Li, P Zhang, D Li, C Feng, Yi, L Zhang,X Ding*, H Li *& Q Du* (2018) Analysis of LncRNA expression in cell differentiation,RNA Biology,15:3, 413-422,

6)P Koirala,J Huang,T Ho,Fwu,X Ding*,Yin-Yuan Mo*,LncRNA AK023948 is a positiveregulator of AKT,Naturecommunication,2017,8:14422-14432

7),,Yang H,Mao W,Chen B,Yang S,Ding X,Zou D,Mo W,He X,Zhang X,. Long non-coding RNAs may serve as biomarkers in breast cancer combined with primary lung cancer,Oncotarget, 2017,8(35):58210-58221

8) B chen,J Liu,T Ho,Y Mo*,X Ding*,ERK-mediated NF-Κbactivation through ASIC1 in response to acidosis,Oncogenesis,2016,7(15):20584-96

9) JHuang, A Zhang, T Ho, Z Zhang, N Zhou,X Ding, X Zhang, Min Xu,and Y Mo,*Linc-RoR promotes c-Myc expression through hnRNP,I and AUF1,Nucleic Acids Research, 2016,44(7):3059-69

10)H Liu, J Li, P Koirala,X Ding,B Chen, Y Wang, Z Wang, C Wang, X, Y Mo Long non-coding RNAs as prognostic markers in human breast cancer,Oncotarget, 2016,7(15):20584-96

11)T Ho, J Huang, N Zhou, ZZhang, PKoirala,XZhou, F Wu,XDing*& Y Mo*,Regulation of PCGEM1 by p54/nrbin prostate cancer,Scientific Reports, 2016,6:34529

12)X Meng,YLi,HTang,W Mao,H Yang,X Wang,X Ding*,Sh Xie,Drug response to HER2 gatekeeper T798M mutationin HER2-positive breast cancer,Amino Acids,2016,48(2), 487-497

13)T Ji, Z Zheng, F Wang, L Xu, L Li, Q Cheng, J Guo,X Ding*,Differential microRNA expression bySolexasequencing in the sera of the ovarian cancer patients.Asian Pacific journal ofcancer prevention, 2014,15: 1739-1743

14)F Yi,F Yang,X Liu,H Chen,T Ji,LJiang,XWang, Z Yang,L Zhang,X Ding*,ZLiang* and QDu*(2013),RNA-seq identified a super-long intergenictranscriptfunctioning in adipogenesis, ,RNA Biology,10:6, 1-12

15)YangF,YiF,ZhengZ, LingZ,DingJ,Guo J,MaoW,WangX,DingX*LiangZ,and DuQ(2012),Characterization of a carcinogenesis-associated long non-codingRNA,RNA Biology, 9(1):110 – 116

16)Ding X*, Ding J, Ning J, Yi F, Zhao D, Zheng J, Liang Z, Hu Z, Du QCirculating microRNA as a potential biomarker for liver injury,Molecular Medicine Reports,2012,5: 1428-1432

17)Wang F, Zheng Z, Guo J andDing X* Correlation and quantitation of microRNA aberrant expression in tissues and sera from patients with breast tumor.Gynecologic Oncology,2010,119(3):586-593.(他引338多次)

18)Huang H, Qiao R, Zhao D, Zhang T, Li Y, Yi F, Lai F, Hong J,Ding X, Yang Z, Zhang L, Du Q, Liang Z* Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs.2009,Nucleic Acids Res. 37(22):7560-7569


代表性专利

1.丁先锋,郭江峰,徐根明,王凤军,一种生物样本中miRNA绝对表达量的检测方法,2011,11,09,专利授权号:ZL 2008 1 0120867.5

2.丁先锋郭江峰,李艳,徐立坚,姚虎,吕佳岚,朱恒怡,microRNA生物标志物及其用途,2012,12,12,专利授权号:ZL 2010 1 0220241.9

3.丁先锋,郭江峰,李艳,徐立坚,姚虎,一种从人血清/血浆样本中分离RNA方法及其PCR验证法,2013,04,04,专利授权号:ZL 2010 1 0220262.6

4.丁先锋,莫寅元,LncRNA及其在作为前列腺癌检测标记物或前列腺癌预后复发标记物中的应用, 专利号:ZL 201510897448.2,专利申请日:2015年12月08日,授权公告日:2018年07月08日,授权公告号:CN 105316341 B


获奖 2016年浙江省自然科学奖三等奖

2020年浙江省科技进步三等奖。




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