学术型硕导
杨东风
日期:2023-12-25 信息来源: 点击数:

   

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杨东风

男,博士,教授,硕士、博士生导师

所在学科组: 生态与植物学

办 公 室: 6#601

电子邮件:ydf807@sina.com


主要学术及社会兼职
浙江省中药材GAP专家工作组成员,药食同源保健食品开发技术浙江省工程研究中心常务副主任,0029cc金沙贵宾会绍兴生物医药研究院副院长,中国中西医结合学会分子生药学专业委员会委员,中国中药协会中药材检测认证技术专业委员会常务委员,中国中药协会药食同源物质评价与利用专业委员会委员,浙江省药学会GAP专业委员会委员,浙江省中医药学会中药资源与鉴定分会常务委员,浙江省植物学会理事,中国丹参产业技术协同创新平台秘书长,《中草药》中英文版青年编委。

研究方向

1天然活性成分生物合成与调控 2、天然药物与药食同源产品开发

手机:15057190968         邮箱:ydf807@sina.com

主要学习工作经历

u 2020.1-至今,0029cc金沙贵宾会绍兴生物医药研究院

u 2012.7-至今 0029cc金沙贵宾会 讲师、副教授、教授

u 2016.9-2017.9 英国John Innes Centre访

u 2013.8-2016.8 0029cc金沙贵宾会天士力博士后

u 2007.9-2012.4 西北农林科技大学药用植物学 博士

u 2005.9-2007.7 西北农林科技大学植物学 硕士

u 2001.9-2005.7 西北农林科技大学生物技术 学士

获奖与荣誉

1. 陕西省植物学会优秀论文一等奖, 2007

2. 陕西省优秀毕业研究生,2010

5. 陕西省优秀博士学位论文,2014

7. 浙江省科学技术三等奖5/72014

8. 0029cc金沙贵宾会521人才,2015

9. 0029cc金沙贵宾会学科建设突出贡献奖,2015

10. 中国商业联合会科技进步特等奖,复方丹参滴丸用优质丹参生产关键技术体系建立与产业化,2/132019

11. 浙江省科学技术进步奖二等奖,大宗药材丹参规范化生产与质量控制关键技术与应用,3/92018

12. 浙江省教学成果一等奖,面向产业发展的生物类专业人才培养的探索与实践,7/152016

13. 浙江省科技进步三等奖,半夏、掌叶半夏miRNA检测及其抗肿瘤蛋白、生物碱类成分分析,5/72013

14. 浙江省中青年学科带头人,2017

15. 浙江省自然基金杰出青年基金获得者 2020

16. 浙江省院士结对培养青年英才计划2020

17. 浙江省万人计划青年拔尖人才,2022

18. 0029cc金沙贵宾会杰出青年教师培养计划,2023

主持项目

1. 国家自然科学基金面上,DNA甲基化和去甲基化协同调控丹参酚酸类成分积累的分子机制(,2020.1-2023.12,主持

2. 国家自然科学基金面上负调控因子SmMYB39与正调控因子SmbHLH7协同调控丹参酚酸类成分生物合成的分子机制2017.1-2020.12,主持

3. 国家自然科学基金青年, 藏丹参中丹参酮类成分高积累的特异性机制研究 , 2015.1-2017.12, 主持

4. 浙江省自然科学基金杰出青年基金,2021.1-2023.12,主持

5. 中央本级重大增减支项目子课题,丹参根系发育调控模块的挖掘及功能解析2023.7.1-2025.12.31,主持

6. 中央本级重大增减支项目子课题,中国丹参近缘种化学成分多样性形成机制及高效催化酶基因挖掘研究2020.9.1-2022.12.31,主持

7. 灵芝酸积累高效调控基因挖掘关键技术及其在灵芝育种中的应用,浙江寿仙谷医药股份有限公司,2022.9-2025.12

专著教材

1. 药用植物学,高等教育出版社,副主编,2020

2. 丹参规范化生产,科学出版社,编委,2014

论文

1. Xinyu He†, Yiwen Chen†, Yuting Xia, Xinyu Hong, Huaqian You, Rui Zhang, Zongsuo Liang, Qi Cui*, Shuncang Zhang*, Ming Zhou*, Dongfeng Yang*, DNA methylation regulates the biosynthesis of tanshinones and phenolic acids during the growth of Salvia miltiorrhiza,Plant Physiology,accepted,2023 IF7.4 TOP

2. Junjie Lin, Xue Yin, Youran Zeng, Xinyu Hong, Shuncang Zhang, Beimi Cui, Qinlong Zhu, Zongsuo Liang, Zheyong Xue*, Dongfeng Yang*,Progress and prospect: biosynthesis of plant natural product based on plant chassis, Biotechnology Advances, 2023,69:108266. IF16 TOP

3. Jie Xia, Xinyu He, Wan Yang, Hongyan Song, Zhenhao Li , Guoliang Zhang, Zongqi Yang, Haimin Chen, Jihong Yang, Zongsuo Liang, Xiaodan Zhang*, Dongfeng Yang*. Unveiling spatial distribution of chemical constituents at different growth periods of Ganoderma lucidum by combining metabolomics with desorption electrospray ionization mass spectrometry imaging (DESI). Food Chemistry, 2023.IF8.8TOP

4. Jie Xia, Ganggui Lou, Lan Zhang, Yanbo Huang, Jian Yang, Juan Guo, Zhechen Qi, Zhenhao Li, Guoliang Zhang, Shengchun Xu, Xijiao Song, Xiaodan Zhang*, Yukun Wei*, Zongsuo Liang*, Dongfeng Yang*, Unveiling the spatial distribution and molecular mechanisms of terpenoids biosynthesis in Salvia miltiorrhiza and S. grandifolia using multi-omics and DESI-MSI, Horticulture Research, 2023, uhad109.IF8.8 TOP

5. Shuncang Zhang*, Lin Qiu, Yuwei Zheng, Wei Wang, Hongguang Zhao & Dongfeng Yang*Comparative transcriptome analysis reveals the regulatory effects of exogenous auxin on lateral root development and tanshinone accumulation in Salvia miltiorrhiza. Planta, 258, 33 (2023)IF4.3

6. You Huaqian, Li Shiqing, Chen Yiwen, Lin Junjie, Wang Zixuan, Dennis Mans, Li Changyu*, Yang Dongfeng*, Global proteome and lysine succinylation analyses provide insights into the secondary metabolism in Salvia miltiorrhiza. Journal of Proteomics, 2023, 288:104959. IF3.3

7. He Xinyu, Chen Yiwen, Li Zhenhao, Fang Ling, Chen Haimin, Liang Zongsuo, Abozeid Ann, Yang Zongqi*, Yang Dongfeng*: Germplasm resources and secondary metabolism regulation in Reishi mushroom (Ganoderma lucidum). Chinese Herbal Medicines 2023, 15(3):376-382. IF3.8

8. Ying Cheng#, Xinyu Hong#, Lan Zhang, Wan Yang, Youran Zeng, Zhuoni Hou, Zongqi Yang* andDongfeng Yang*, Transcriptomic analysis provides insight into the regulation mechanism of silver ions (Ag+ ) and jasmonic acid methyl ester (MeJA) on secondary metabolism in the hairy roots of Salvia miltiorrhiza Bunge (Lamiaceae). Medicinal Plant Biology, 2023. 2:3

9. Chen Yue, Wang Yanting, Guo Juan, Yang Jian, Zhang Xiaodan, Wang Zixuan, Cheng Ying, Du Zewei, Qi ZheChen, Huang YanBo, Dennis Man, Wei Yukun*, Yang Dongfeng*, Huang Luqi*, Liang Zongsuo*, Integrated Transcriptomics and Proteomics to Reveal Regulation Mechanism and Evolution of SmWRKY61 on Tanshinone Biosynthesis in Salvia miltiorrhiza and Salvia castanea. Frontiers in plant science 2022, 12820582. IF5.6 TOP

10. Zhang Shuncang, Zhang Lei, Zou Haiyan, Qiu Lin, Zheng Yuwei, Yang Dongfeng*, Wang Youping*, Effects of Light on Secondary Metabolite Biosynthesis in Medicinal Plants. Frontiers in plant science 2021, 12781236. IF5.6 TOP

11. Feiyan Wang, Huaqian You, Yanhong Guo, Yukun Wei, Pengguo Xia, Min Ren, Hui Guo, Ruilian Hang, Dongfeng Yang*, Essential oils from three kinds of fingered citrons and their antibacterial activities, Industrial Crops and Products,2020, 147:112172. IF5.9 TOP

12. Yang Dongfeng, Huang Zhicheng, Jin Weibo, Xia Pengguo, Jia Qiaojun, Yang Zongqi, Hou Zuoni, Zhang Haihua, Ji Wei and Han Ruilian*, DNA methylation: A new regulator of phenolic acids biosynthesis in Salvia miltiorrhiza, Industrial Crops and Products, 2018124402-411 TOP

13. Fang Yumin, Hou Zuoni, Zhang Xiaodan, Yang Dongfeng* and Liang Zongsuo*, Diverse specialized metabolism and their responses to lactalbumin hydrolysate in hairy root cultures of Salvia miltiorrhiza Bunge and Salvia castanea Diels f. tomentosa Stib, Biochemical Engineering Journal, 201813158-69

14. Dongfeng Yang, Zhicheng Huang, Bingcong Xing,Weibo Jin,Xijun Yan, Zhixin Guo, Zongsuo Liang, Regulation of folic acid on phenolic acids production in Salvia miltiorrhiza hairy roots, ,2016, 127(1): 175–185.

15. Yang, D.F, Du, X., Yang, Z., Liang, Z., Guo, Z., & Liu, Y. Transcriptomics, proteomics, and metabolomics to reveal mechanisms underlying plant secondary metabolism. Engineering in Life Sciences, 2014, 14,(5): 456-466.

16. Yang, D. F., Ma, P. D., Liang, X., Wei, Z., Liang, Z. S., Liu, Y., Liu, F. H., PEG and ABA trigger methyl jasmonate accumulation to induce the MEP pathway and increase tanshinone production in Salvia miltiorrhiza hairy roots, Physiologia Plantarum, 2012, 146(2):173-183.

17. Yang, D.F., Sheng, DF, Duan, Q.M., Liang, X., Liang, Z.S., Liu, Y., PEG and ABA Trigger the Burst of Reactive Oxygen Species to Increase Tanshinone Production in Salvia miltiorrhiza Hairy Roots, Journal of Plant Growth Regulation, 2012, 31(4):579-587.

18. 孙国志,段宝忠,黄文昊等. 基于活性成分比例一致性的白芷药材质量评价数据挖掘 [J]. 中草药, 2023, 54 (16): 5329-5338.

19. 林俊杰,杜旭红,梁宗锁等. 不同培养基对丹参和绒毛鼠尾草毛状根生长及有效成分积累的影响 [J]. 时珍国医国药, 2023, 34 (03): 692-697.

20. 杨东风,梁宗锁. 基于有效成分比例一致性的三维多组分中药质量评价研究——以丹参为例[J]. 中国中药杂志,2022,47(11):3118-3124.

21. 娄港归, , , 王宏鹏, 梁宗锁, , 李振达, , 刘志超, 施宛丽, 张晓丹*, 杨东风*,基于UPLC-Q-TOF-MS/MS代谢组学的铁皮石斛和玫瑰石斛化学成分差异研究,药学学报 Acta Pharmaceutica Sinica 2021, 56(12): 3331 −3344

22. 王飞艳,尤华乾,杜旭红,杨宗岐,张晓丹,梁宗锁*,杨东风*.不同氮源对丹参和藏丹参毛状根有效成分积累的影响[J].中草药,2020,51(09):2538-2547.

23. 郭妍宏,王飞艳,尤华乾,魏宇坤,杨宗岐,梁宗锁*,杨东风*.不同碳源对丹参和藏丹参毛状根生长及活性成分积累的影响[J].中国中药杂,2020,45(11):2509-2514

24. 金雯芳,沈丽红,任加惠,金江淼,沈忆奕,朱君俏,梁宗锁*杨东风*,佛手精油及相关产品开发的研究进展,中草药,475:857

25. 沈丽红,任加惠,金雯芳,王瑞杰,倪春红,童梦姣,梁宗锁*杨东风*,一氧化氮信号在脱落酸诱导丹参酚酸类成分积累中的作用,生物工程学报,2016, 32(5): 1−9

专利

1.杨东风,梁宗锁,陈玮,王瑞杰,杜旭红,邢丙聪,方誉民,毛状根专用生物反应器,授权号:CN205099687UZL2015207522553实用新型授权,2016.03.23

2.杨东风,梁宗锁,杜旭红,刘岩,王瑞杰,何燕峰,倪春红能够促进丹参毛状根中丹酚酸积累的诱导方法ZL201410687372.6发明专利2017-05-03

3.杨东风,梁宗锁,贾巧君,夏鹏国,侯卓妮,方誉民,杜旭红提高藏丹参毛状根中丹参酮类成分含量的方法ZL201610675780.9发明专利2018-04-17

4.梁宗锁,杨东风,韩名宇,郭万里,杨宗岐,金伟波,刘岩能够促进丹参毛状根中丹参酮积累的诱导方法ZL201410689796.6发明专利2016-08-24

5.梁宗锁,杨东风,黄志成,郭万里,祁哲晨,张晓丹促进丹参毛状根中迷迭香酸和丹酚酸B积累的诱导法ZL2014107356360发明专利2016-08-24

6.梁宗锁,杨东风,黄志成,吕洪飞,侯卓妮,杜旭红促进丹参毛状根中迷迭香酸和丹酚酸B积累的方法ZL201410697396X发明专利2016-08-24




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