学术型硕导
陈侃
日期:2022-05-16 信息来源: 点击数:

陈侃



学科/系:细胞生物学学科组/生物技术系

办公室:#6-309

职称:副教授

Email: chenkan_xjtu@163.com; chenkan@zstu.edu.cn


简介:医学博士,副教授,硕士生导师,博士毕业于荷兰伊拉斯姆斯大学医学中心肝肠胃病专业,博士期间曾获欧洲肝病年会“青年科学家”称号。现就职于0029cc金沙贵宾会登录,主讲《免疫学》、《Immunology》(留学生课程),《生物技术综合实验》等课程。主持国家自然科学基金面上项目1项,浙江省自然科学基金面上项目1项,其他省级课题3项,发明专利5项。以第一或通讯作者发表SCI论文十余篇,多次应邀参加国际学术会议并进行学术成果口头汇报。兼任多个国际学术杂志审稿人。参编出版高等教育出版社数字化课程一门,荣获全国高校生命科学类微课教学比赛一等奖,0029cc金沙贵宾会教书育人先进个人,0029cc金沙贵宾会优秀寝室成长导师,0029cc金沙贵宾会“百篇优秀毕业论文”指导教师,0029cc金沙贵宾会登录教学先进个人等称号。多次指导本科生获得新苗、国创、生命科学竞赛等项目。


研究领域:

1. 慢性肝病(主要包括非酒精性脂肪肝、脂肪型肝炎、肝癌)的预防与治疗;

2. 基于溶瘤痘苗病毒的肝癌靶向治疗。

科研课题

1.国家自然科学基金面上项目,IMPDH/PPAR信号通路调控肝癌的机制及其靶向干预研究(81972281),2020/01-2023/12,在研,主持

2.浙江省自然科学基金一般项目,霉酚酸和IMPDH在肝癌进展中的关联效应研究(LY18H160066),2018/01-2020/12,已结题,主持

3. 浙江省科技厅分析测试项目,运用流式细胞术快速检测腺病毒滴度(2012F82G2060018),2012/01-2014/01,已结题,主持

4.浙江省“生物医学工程”重中之重开放基金,肝癌干细胞的分选、鉴定及其生物学特性的研究(SWYX0812),2009/01-2010/12,已结题,主持

5.浙江省教育厅一般项目,肝癌干细胞的分选、鉴定及其表面抗原的筛选(20060593),2006/07-2008/12,已结题,主持

6.浙江省自然科学基金重点项目,癌症靶向双基因-病毒治疗策略的设计及其抗癌效果的实验研究(LZ13H160004),2013/01-2016/12,已结题,3/7

7.浙江省科技厅平台项目,浙江-毛里求斯(浙理)生物医用材料与组织工程联合研究中心,2019/03-2023/07200万,在研,5/6

8.溶瘤病毒特色技术的开发与应用,杭州功楚生物科技有限公司, 2018.09-2019.09, 横向,160万,已结题,3/3

9.溶瘤病毒的研究与应用,杭州功楚生物科技有限公司,2019.09-2021.03,横向,240万,在研,3/3.

参加国际会议

l 头报告

2019,the International Symposium on Biomedicine and Biomaterials (ISBB)

2016,the 9th Dutch Experimental Gastroenterology and Hepatology (DEGH)

l 墙报展示

1. 2016,The 51th Annual Meeting of the European Association for the Study of the Liver (EASL), Barcelona, Spain

2. 2016,The 20th  Annual Molmed Day, Molecular Medicine Postgraduate School, Rotterdam, The Netherlands

3. 2015,The 19th  Annual Molmed Day, Molecular Medicine Postgraduate School, Rotterdam, The Netherlands

4. 2014,The 49th Annual Meeting of the European Association for the Study of the Liver (EASL), London, United Kingdom

5. 2014,The 18th  Annual Molmed Day, Molecular Medicine Postgraduate School, Rotterdam, The Netherlands

6. 2014,The International Liver Transpaltation Society (ILTS ) annual congress


代表性论文

1. X Jia, Y Liu, Y Chen, Y Wang, H Kang, Z Ma, K Chen*, Inosine monophosphate dehydrogenase type1 sustains tumor growth in hepatocellular carcinoma. J Clin Lab Anal. 2022;00:e24416. (IF2020=2.213)

2. J Ni, H Feng, X Xu, T Liu, T Ye, K Chen*, G Li*. Oncolytic vaccinia virus harboring aphrocallistes vastus lectin inhibits the growth of cervical cancer cells hela S3. Mar. drugs, 2021, 19, 532. (IF2020=5.118)

3. J Ma, Y Chen, Q Su, W Ai, L Gong, Y Wang, L Li, Z Ma, Q Pan, Z Qiao, K Chen*, Effects of intermittent fasting on liver physiology and metabolism in mice. Experiment and Theraputic Medicine 2021, 22: 950. ((IF2020=2.447)

4. X Jia, Y Zheng, Y Guo, K Chen*, Sodium butyrate and panobinostat induce apoptosis of chronic myeloid leukemia cells via multiple pathways. Mol Genet Genomic Med. 2019, May,7(5):e613. (IF2020=2.183)

5. K Chen, J Ma, X Jia, W Ai, Z Ma, Q Pan*. Advancing the understanding of NAFLD to hepatocellular carcinoma development: from experimental models to humans. BBA reviews on cancer. 2019 Jan, 1871(1):117-125. (IF2020=10.68)

6. K Chen, J Sheng, B Ma, W Cao, P Y Hernanda, J Liu, P P. C. Boor, S. W. Tjon, K Felczak, D Sprengers, K W. Pankiewicz, H J. Metselaar, Z Ma, J Kwekkeboom, M P. Peppelenbosch, Q Pan*. Suppression of hepatocellular carcinoma by mycophenolic acid in experimental models and in patients. Transplantation. 2019 May, 103(5):929-937. (IF2020=4.939)

7. K Chen, B Ma,  MP Q *. Cytoplasmic rods and rings in mycophenolic acid treatment. Letter, 2017, 37(11):1742-1743. (IF2020=5.828)

8. K Chen, K Sideras, B Ma, W Cao, L J van de Laan, D Sprengers, R Smits, H J Metselaar, J Kwekkeboom, M P Peppelenbosch, Q Pan*. Nuclear localization of IMPDH2, the primary target of mycophenolic acid, constrains hepatocellular carcinoma. J Hepatology, supplement, 2016, 64(20): S567. (IF2020=25.083)

9. K Chen, W Cao, J Li, D Sprengers, P Y. Hernanda, X Kong, Luc J. W. van der Laan, K Man, J Kwekkeboom, H J. Metselaar, M P. Peppelenbosch, Q Pan*. Differential Sensitivities of Fast- and Slow-cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by Mycophenolic Acid. Mol Med. 2016, 21(1):792-802. (IF2020=6.354)

10. P Y Hernanda, K Chen (co-first author), A M Das, K Sideras, W Wang, J Li, W Cao, S J A Bots, L L Kodach, R A de Man, J N M Ijzermans, H L A Janssen, A P Stubbs, D Sprengers, M J Bruno, H J Metselaar, T L M ten Hagen, J Kwekkeboom, M P Peppelenbosch, Q Pan*. SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma. Oncogene, 2015, 34(39):5055-5068. (IF2020=9.867)

11. K Chen, K Man, H J Metselaar, H L A Janssen, J Kwekkeboom, D Sprengers, M J Bruno, M P Peppelenbosch, Q Pan*. IMPDH2-targeted constrain of cell growth in hepatocellular carcinoma by mycophenolic acid. J Hepatology, supplement, 2014, 60(1): S88. (IF2020=25.083)

12. K Chen, K Man, H J. Metselaar, H L. A. Janssen, M P. Peppelenbosch, Q Pan*. Rationale of personalized immunosuppressive medication for hepatocellular carcinoma patients after liver transplantation. Liver Transpl. 2014, 20 (3); 261-269. (IF2020=5.799)

13. K Chen, Q Pan, Y Gao, X Yang, S Wang, M P. Pepplenbosch, X Kong*. DMS triggers apoptosis associated with inhibition of SPHK1/NF-κB activation and increase of intracellular Ca2+ concentration in human cancer cells. Int J Mol Med. 2014, 33(1):17-24. (IF2020=4.01)

14. K Chen, X Yang, L Wu, M Yu, X Li, N Li, S Wang, G Li*. Pinellia pedatisecta Agglutinin Targets Drug Resistant K562/ADR Leukemia Cells through Binding with Sarcolemmal Membrane Associated Protein and Enhancing Macrophage Phagocytosis. PLoS ONE. 2013, 8(9); e74363. (IF2020=2.74)

15.  W Cao, M Li, S Zhang, L Noordam, MMA Verstegen, L Wang, B Ma, W Wang, M Bolkestein, M Doukas, K Chen, Z Ma, M Bruno, D Sprengers, J Kwekkeboom, LJW van der Laan, R Smits, MP Peppelenbosch, Q Pan. LGR5 marks targetable tumor-initiating cells in mouse liver cancer. Na Commun, 2020 Apr23;11(1):1961. (IF2020=14.919)

16. W K Chen, M Bolkestein, Y Yin, MMA Verstegen, MJC Bijvelds, W Wang, N Tuysuz, B D Ten, D Sprengers, HJ Metselaar, LJW van der Laan, J Kwekkeboom, R Smits, MP Peppelenbosch, Q Pan*. Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury. Gastroenterology. 2017,153(4):1133-1147. (IF2020=17.373)

17. Y Wang, X Zhou, Y Debing, K Chen, L JW. Vander Lanna, J Neyts, H L.A. Janssen, He J. Metselaar, M P Peppelenbosch, Q Pan*. Calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis E virus. Gastroenterology, 2014, 146(7);1775-83. (IF2020=17.373)






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