副教授
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金甲
日期:2023-01-10 信息来源: 点击数:

2金甲,博士,副教授,硕士生导师

生物制药系副主任

地址:浙江省杭州市钱塘新区2号大街928

E-mailaukaukauk@163.com

所在学科组:生物制药办公室:6-417

 

教育及研究经历

2003.92007.6 上海师范大学化学工程与工艺工学学士

2007.92010.6 上海师范大学有机化学理学硕士(导师:薛思佳教授)

2010.92013.6 华东师范大学有机化学理学博士(导师:杨帆教授,汤杰教授;合作导师:李静雅研究员,李佳研究员)

2019.42020.7加州大学旧金山分校药物化学系访问学者(合作导师,William F. DeGrado/美国科学院院士、美国艺术与科学院院士)

2013.72022.120029cc金沙贵宾会登录讲师(硕士生导师)

2022.12~至今0029cc金沙贵宾会登录副教授(硕士生导师)

 

主要研究方向

1.       药物化学

2.       生物医用材料

主要科研和教学成果

主持国家自然科学基金一项,浙江省自然科学基金和浙江省科技厅项目各一项,横向课题十多项,参与国家级、省级项目多项。在包括JACSPNASDiabetesTheranosticsJMCIJBMColloids and Surfaces B:Biointerfacestop期刊共发表SCI论文33篇,共被引用420次以上,单篇最高引用超过75次,申请专利14项,已获授权10项。

主要学术与社会兼职

中国药学会会员、中国化学会会员,0029cc金沙贵宾会登录——嘉兴市第一医院联合研究中心主任,JACS等多个SCI期刊审稿人

 

主要研究工作

1)        新型靶向PRMT家族小分子抑制剂研究(上海药物所、华东师范大学联合研究,相关国家自然科学基金2项,省自然科学基金2项,已发表相关SCI论文8篇,其中SCI top期刊2篇,申请专利3项,已获授权1项)

2)        新型医用可吸收止血剂开发和应用(浙江三创生物科技有限公司产品研发,目前相关企业研究课题6项,完成6项,省科技厅项目1项,发表相关SCI论文7篇,其中SCI top期刊2篇,相关专利授权8项,产品进入临床研究和产品申报阶段)

3)        β-Amyloid相关蛋白(Tau等)的分子诊断探针应用和结构生物学研究(UCSF联合研究,已发表相关SCI top期刊2篇)。

4)        基于线粒体靶向的小分子药物研究(华东师范大学、上海药物所联合研究,相关上海市课题2项,发表核心期刊1篇,SCI top期刊1篇,相关专利授权2项)

5)        用于II型糖尿病治疗的PTP1b靶向药物筛选(南通大学、上海应用技术大学联合研究,相关江苏省自然基金1项,委托测试项目1项,发表SCI论文2篇,相关专利授权1项)

 

主持和参与科研项目及课题

1.      国家自然科学基金青年基金项目:“新型选择性CARM1抑制剂的设计、合成及生物活性研究”(NO.81803339,主持)

2.      浙江省自然科学基金探索项目:“辅激活相关精氨酸甲基转移酶蛋白降解剂的设计、合成与抗肿瘤活性研究”(主持)

3.      浙江省公益技术研究工业项目:“新型抗菌复合可吸收止血微球产业化关键技术研究”(NO.2016C31017主持

4.      0029cc金沙贵宾会青年创新专项:“新型仿血小板生物止血材料的关键制备技术和应用研究”(NO.19042223-Y,主持

5.      医院委托技术服务项目:“医药领域前沿发展动态分析与研究”(主持)

6.      企业委托技术开发项目:“基于人工智能和大数据AI技术的创新农药开发”(主持)

7.      企业委托技术开发项目:“齐考诺肽注射液的制剂工艺技术开发”(主持)

8.      医院委托技术服务项目:“PRMT1抑制剂的活性测试”(主持)

9.      企业委托技术服务项目:“可吸收止血微球的相关试验”(主持)

10.   企业委托技术开发项目:“壳聚糖类生物医用材料相关原料及工艺中病毒灭活的开发研究(主持)

11.   企业委托技术开发项目:“壳聚糖类生物医用材料相关产品工艺开发(主持)

12.   企业委托技术开发项目:“CSC可吸收止血微球相关产品工艺开发(主持)

13.   企业委托技术开发项目:壳聚糖类生物医用材料相关原料在产品中残留的检测方法开发研究(主持)

14.   高校委托技术服务项目:“PTP1b先导化合物的酶活检测(主持)

15.   国家自然科学基金项目:靶向menin-MLL相互作用界面的药物发现与药物设计NO.81402849,参与)

16.   国家自然科学基金项目:Z)型四氢嘧啶类昆虫乙酰胆碱受体抑制剂的分子设计及先导化合物优化研究NO.21042010,参与)

17.   浙江省自然科学基金一般项目:“针对蛋白质精氨酸甲基转移酶PRMT1的药物发现与化学干预研究”(NO.LY18H300008,参与)

18.   浙江省科技厅公益技术应用研究项目:基于金黄色葡萄球菌ClpP的抗菌药物发现与药物设计NO.2015C33159,参与)

19.   高校委托技术服务项目:“PRMT1 小分子抑制剂应用于抗肿瘤治疗的药物研发和产业化”(参与)

20.   企业委托技术开发项目:“二巯基丙醇及特殊高分子树脂公斤级合成工艺开发”(参与)

21.   企业委托技术开发项目:“新型抗菌肽的开发”(参与)

22.   企业委托技术开发项目:“注射用胸腺五肽长效制剂研究开发”(参与)

23.   企业委托技术开发项目:“基因重组生长激素中试工艺研究”(参与)

24.   企业委托技术开发项目:“乳猪肝脏提取物促肝细胞生长素有效成分的筛选和主要质量标准探究”(参与)

25.   企业委托技术开发项目:“家蚕生物反应器生产抗轮状病毒疫苗的研究”(参与)

26.   企业委托技术开发项目:“可吸收止血微球及附件"产品中辅助试剂的残留量检测方法开发研究”(参与)

27.   企业委托技术开发项目:“加巴喷丁对肩周炎的治疗作用研究”(参与)

28.   上海市科委科学仪器与化学试剂研究项目(NO. 11142200702NO. 12142200802,参与)

29.   上海市教委重点科技攻关项目:具有生物活性的新型稠杂环化合物的优化研究NO. 07zz69,参与)

30.   上海市科委科技成果转化项目:创新除草剂苯氧嘧草胺的的开发NO. 083919n0800,参与)

31.   上海市重点科技攻关项目:“(Z)式构型的新烟碱类杀虫剂先导化合物的研究NO. 09391212100,参与)

32.   浙江省自然科学基金项目: “鬼臼毒素类衍生物抗肿瘤纳米靶向制剂研究NO.Y2081030,参与)

 

发表文章

1.         Haofeng Hu, Fulin Luo,QianZhang, MingXu, XinChen, ZhihaoLiu, HaodongXu, LeiWang, FeiYe, KuiZhang, BinChen, SongZheng, Jia Jin*. Berberine coated biocomposite hemostatic film based alginate as absorbable biomaterial for wound healing. International Journal of Biological Macromolecules, 2022, 209, 1731-1744. (Top Journal)

2.         Weiwei Zeng, Nga-man Cheng, Xia Liang, Haofeng Hu, Fulin Luo, Jia Jin*&Ya-wei Li*. Electrospun polycaprolactonenanofibrous membranes loadedwith baicalin for antibacterialwound dressing. Scientific Reports, 2022, 12, 10900.

3.         Xiao Li, Lun Zhang, Jing Xu, Chenyu Liu, Xiaojian Zhang, Amr Abbas Abdelmoneim, Qian Zhang,JiaqiKe, Yingnan Zhang, Lei Wang, Fan Yang, Cheng Luo, Jia Jin* and Fei Ye*. Identification, Synthesis, and Biological Evaluations of PotentInhibitors Targeting Type I Protein Arginine Methyltransferases.Journal of Chemical Information and Modeling, 2022, 62, 692-702.

4.         Ketaki D. Belsare, Haifan Wu, Dibyendu Mondal, Annalise Bond, Erika Castillo, Jia Jin, Hyunil Jo,Addison E. Roush, Kala Bharath Pilla, Andrej Sali, Carlo Condello, and William F. DeGrado*. Soluble TREM2 inhibits secondary nucleation of Aβfibrillization and enhances cellular uptake offibrillar Aβ. PNAS, 2022, 119, e2114486119. (Top Journal)

5.         Qian Zhang, Lun Zhang, Jia Jin, Yaohua Fan, Xiaoguang Wang, Haofeng Hu, Xiaoqing Ye, Lei Wang, Chenxi Cao*, Fei Ye*. Identification of PRMT5 inhibitors with novel scaffold structures through virtual screening and biological evaluations. Journal of Molecular Modeling 28(7), 1-9.

6.         Aurelio J. Dregni, Harrison K. Wang, Haifan Wu, Pu Duan, Jia Jin, William F. DeGrado,and Mei Hong*. Inclusion of the C‑Terminal Domain in the β‑Sheet Core of Heparin-Fibrillized Three-Repeat Tau Protein Revealed by Solid-StateNuclear Magnetic Resonance Spectroscopy. Journal of the AmericanChemical Society, 2021, 143, 7839-7851. (Top Journal)

7.         Lei Wang*, Meng Xu, Haofeng Hu, Lun Zhang, Fei Ye,Jia Jin, Hongming Fang, Jian Chen, Guiqian Chen, Sylvain Broussy, Michel Vidal, ZhengbingLv, Wang-Qing Liu*. A Cyclic Peptide Epitope of an Under-Explored VEGF-B Loop 1 Demonstrated In Vivo Anti-Angiogenic and Anti-Tumor Activities. Frontiers in pharmacology, 2021, 12, 734544.

8.         Jianfeng Wang1, Chen Wang1, Pan Xu1, Xiao Li, Yongning Lu, Di Jin, Xiaomao Yin, Hao Jiang, Jing Huang, Huan Xiong, Fei Ye, Jia Jin, Yu Chen, Yiqian Xie, Zhifeng Chen, Hong Ding, Hao Zhang, Rongfeng Liu, Hualiang Jiang, Kaixian Chen, Zhiyi Yao, Cheng Luo*, Yiran Huang*, Yuanyuan Zhang*, Jin Zhang*. PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Theranostics, 2021, 11(11): 5387.(Top Journal)

9.         Xiaojian Zhang, Kaili Dai, Chenyu Liu, Haofeng Hu, Fulin Luo, Qifan Qi, Lei Wang, Fei Ye,Jia Jin*, Jie Tang*, and Fan Yang*. Berberine-Coated Biomimetic Composite Microspheres forSimultaneously Hemostatic and Antibacterial Performance. Polymers, 2021, 13(3), 360.

10.     Jia Jin*, Ming Xu, Yixuan Liu, Zhixiao Ji, Kaili Dai, Lun Zhang, Lei Wang, Fei Ye,Gang Chen*, ZhengbingLv*. Alginate-based composite microspheres coated by berberine simultaneouslyimprove hemostatic and antibacterial efficacy.Colloids and Surfaces B: Biointerfaces, 2020, 194, 111168.(Top Journal)

11.     X Ye, G Chen, J Jin, B Zhang, Y Wang, F Ye. The development of inhibitors targeting the mixed lineage leukemia 1 (MLL1)-WD repeat domain 5 protein (WDR5) protein-protein interaction.Current Medicinal Chemistry, 2020.

12.     H Jiang, J Jin, Y Duan, Z Xie, Y Li, A Gao, M Gu, X Zhang, C Peng, C Xia, ...Mitochondrial uncoupling coordinated with PDH activation safely ameliorates hyperglycemia via promoting glucose oxidation.Diabetes,2019, 68 (12), 2197-2209.(Top Journal)

13.     J Jin*, X Ye, D Boateng, K Dai, F Ye, P Du, H Yu*. Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B). Bioorganic & Medicinal Chemistry Letters,2019, 29 (16), 2358-2363

14.     X Ye, R Zhang, F Lian, W Zhang, W Lu, J Han, N Zhang, J Jin, C Luo*, ...The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorganic & medicinal chemistry letters,2019, 29 (4), 638-645.

15.     W Wu, T Liu, H He, X Wu, X Cao, J Jin, Q Sun, VAL Roy, RKY Li.Rhelogical and antibacterial performance of sodium alginate/zinc oxide composite coating for cellulosic paper.Colloids and surfaces B: Biointerfaces,2018, 167, 538-543.(Top Journal)

16.     Jia Jin*, Zhixiao Ji, Ming Xu, Chenyu Liu, Xiaoqing Ye, Weiyao Zhang, Si Li, Dan Wang, Wenping Zhang, Jianqing Chen, Fei Ye*, ZhengbingLv*. Microspheres of Carboxymethyl Chitosan, Sodium and Collagen as a Hemostatic Agent in vivo. ACS Biomaterials Science & Engineering,2018, 4, 2541-2551.

17.     Fei Ye*, Weiyao Zhang, Xiaoqing Ye, Jia Jin, ZhengbingLv, and Cheng Luo*. Identification of Selective, Cell Active Inhibitors of Protein ArginineMethyltransferase 5 through Structure-Based Virtual Screening andBiological Assays. Journal of Chemical Information and Modeling, 2018, 58, 1066-1073.

18.     Fei Ye1,Xiangqian Kong1, Hao Zhang, Yan Liu, Zhiyuan Shao,Jia Jin, Yi Cai, Rukang Zhang, Linjuan Li, Yang W. Zhang, Yu-Chih Liu, Chenhua Zhang, WenbingXie, Kunqian Yu, Hong Ding, Kehao Zhao, Shijie Chen*, Hualiang Jiang, Stephen B. Baylin* and Cheng Luo*. Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNMT1, ACS Chemical Biology, 2018, 13, 772-781.

19.     Wang, Chen1 ; Jiang, Hao1 ; Jin, Jia1; Xie, Yiqian; Chen, Zhifeng; Zhang, Hao; Lian, Fulin; Liu, Yu-Chih; Zhang, Chenhua; Ding, Hong; Chen, Shijie; Zhang, Naixia; Zhang, Yuanyuan ; Jiang, Hualiang; Chen, Kaixian; Ye, Fei*; Yao, Zhiyi*; Luo, Cheng*. Development of potent type i protein arginine methyltransferase (PRMT) inhibitors of leukemia cell proliferation,Journal of Medicinal Chemistry, 2017.10.11, 60(21): 8888~8905.(Co-first author, Top Journal)

20.     Zhang, weiyao1; Lu, wenchao1; Jiang, hao; Lv, zhengbing; Xie, yiqian; Lian, fulin; Liang, zhongjie; Jiang, yuxi; Wang, dajin; Luo, chen;Jin, Jia*;Ye, fei*. Discovery of alkyl bis (oxy) dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors,Chemical Biology & Drug Design, 2017.7.19, 90(6): 12601270.

21.     Xinyi Shi, Qiang Fang, Miao Ding, Jing Wu, Fei Ye, ZhengbingLv and Jia Jin*.Microspheres of carboxymethyl chitosan, sodium alginate and collagen for a novel hemostatic in vitro study,Journal of Biomaterials Applications.2016, 30, 1092–1102.

22.     Haibing He, Yinghua Ge, Hong Dai, Song Cui, Fei Ye, Jia Jin*, Yujun Shi*. Design, synthesis and biological evaluation of stilbene derivatives as novel inhibitors of protein tyrosine phosphatase 1B,Molecules, 2016, 21(12): 1722-1733.

23.     Fei Ye, Weiyao Zhang, Wenchao Lu, Yiqian Xie, Hao Jiang, Jia Jin*, Cheng Luo*. Identification of novel inhibitors against coactivator associated arginine methyltransferase 1 based on virtual screening and biological assays,Biomed Research International.2016, 01, 7086390.

24.     Wenping Zhang, Jian Wang, Chen Zhang, Qiang Fang, Jianhong Shu, Si Li, Jia Jin, Dan Wang, ZuomingNie, ZhengbingLv, Yaozhou Zhang*. Synergetic Protein Factors That Improve rhGM-CSF Absorption via an Oral Route Exist in Silkworm Pupae,Molecular Pharmaceutics, 2015, 12(5): 1347-1355.

25.     Jia Jin, Yifan Shan, Fan Yang, Hua Lai, Hongwei Tan, Xiaofeng Liu, Jie Tang*, Qiang Fang*.Organic photosensitizers with N-carboxymethyl pyridinium acceptor/anchoring group for dye-sensitized solar cells,Synthetic Met.2012, 162, 2222-2227.

26.      Chuanwen Sun*, Jun Zhu, Haifeng Wang,Jia Jin, Jiahua Xing, Dingrong Yang.Chiral 1, 5-disubstituted 1, 3, 5-hexahydrotriazine-2-N-nitroimine analogues as novel potent neonicotinoids: Synthesis, insecticidal evaluation and molecular docking studies,European Journal of Medicinal Chemistry.2011, 46, 11-20.

27.     Chuanwen Sun*, Jia Jin, Jun Zhu, Haifeng Wang, Dingrong Yang, JiahuaXing.Discovery of bis-aromatic ring neonicotinoid analogues fixed as cis-configuration: Synthesis, insecticidal activities, and molecular docking studies,Bioorg. Med. Chem. Lett.2010, 20, 3301–3305.

28.     Chuan-wen Sun*, Jun Zhu,Jia Jin and Yang Ding-rong.Acta Cryst Section E.2010, 66, o1457-o1458.

29.     Chuanwen Sun*, Dingrong Yang, Haifeng Wang, Jia Jin, Jun Zhu.Nitromethylene Neonicotinoids Analogues with Tetrahydropyrimidine Fixed cis-Configuration: Synthesis, Insecticidal Activities, and Molecular Docking Studies, J. Agric. Food. Chem.2010, 58, 3415–3421.(Top Journal)

30.     Zhu Jun, SijiaXue*, Haifeng Wang, Yang Ding-Rong,Jin Jia.Syntheses and Crystal Structures of 1, 5-Disubstituted 1, 3, 5-Hexahydro-triazine-2-(N-nitro) imines,Chinese J. Struct. Chem.2010, 3, 400-406.

31.     Dingrong Yang,SijiaXue*, Haifeng Wang, Jun Zhu, Jia Jin, Jun Chen. J. Mol. Struc.2009, 929, 97–104.

32.     J. Jin, S.-J. Xue*, X.-F. Li and Z.-K. Fang.(+)-[1-(4-Methoxybenzyl) pyrrolidin-2-yl] diphenylmethanol,Acta Cryst Section E.2009, 65, o1035.

33.     Haifeng Wang, SijiaXue*, Zhu Jun, Yang Ding-Rong, Jin Jia, Fang Zhi-Kun.Synthesis, Crystal Structure and Bioactivity of N-Phenethyl-4-hydroxy-4-phenyl Piperidine Hydrochloride, Chinese J. Struct. Chem.2009, 28, 742-746.

 

专利

1.   金甲,杨帆,叶飞,王磊,刘陈育,张晓健,刘志豪,张伦,一种具有IPRMT抑制活性的化合物及其应用,专利申请号:202210733537.3(已受理)

2.   叶飞,金甲,王磊,PRMTI型甲基转移酶抑制活性化合物及其制备与应用,专利申请号:202110811481.4(已受理)

3.   叶飞,金甲,王磊,徐明,张文平,舒建洪,吕正兵,一种抗菌止血膜及其制备方法和应用,专利申请号:202110059037.1(实质审查阶段)

4.   金甲,叶飞,吕正兵,张楠,姚颖洁,代凯丽,季志孝,徐明,一种含小檗碱的抗菌止血微球的制备方法及其应用,专利申请号:201811225912.3(已授权)

5.   叶飞,金甲,代凯丽,王林,张伦,一种含抗菌成分小檗碱的止血微球及其制备方法和应用,专利申请号:201811483221.3(已授权)

6.   刘陈育,叶飞,金甲,张楠,姚颖洁,代凯丽,季志孝,徐明,吕正兵,可吸收仿血小板生物质材料及其应用,专利申请号:201810247846.3(已授权)

7.   罗成,金甲,谢轶谦,姚志艺,叶飞,王晨,蒋昊,张元元,陆文超,蒋华良,PRMTI型抑制剂及其制备方法和用途,专利申请号:201710348647.7(已授权)

8.   金甲,杨玉民,叶飞,一种可吸收抗菌止血微球、制备方法及其应用,专利申请号:201610526892.8(实质审查阶段)

9.   舒建洪,吕正兵,金甲,张超,朱浩艳,叶速东,一种抗菌促生长动物专用药3-甲基-2-乙醇基喹噁,专利申请号:201611203253.4(已授权)

10.  金甲,于晗,叶飞,吕正兵,一种含二氢吡啶硫酮类化合物或其药学上可接受的盐、制备及其应用,专利申请号:201610516463.2(已授权)

11.  舒建洪,吕正兵,金甲,张超,朱浩艳,叶速东,一种饲料添加剂脱镁叶绿素的提取方法,专利申请号:201611229326.7(已授权)

12.  金甲,吕正兵,叶飞,张文平,舒建洪,一种苯并三氮唑类衍生物及其制备方法,专利申请号:201410466706.7(已授权)

13.  汤杰、李佳、金甲、蒋昊文、李静雅、杨帆、杨玲玲、何海兵、盛丽、于丽芳、张杰锋、阮礼波、石敏、李念,N-(1,3-二氧代异吲哚啉)芳酰胺类化合物及其制备方法和应用,专利申请号:201410410345.4(已授权)

14.  薛思佳,杨定荣,金甲,陈志明,方治坤,含L-α-氨基酸脂的Z式构型新烟碱类杀虫剂及制备,专利申请号:200910057324.8(已授权)

 


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